Nordic Research Papers You May Have Missed (5 February 2021)

11 February 2021. What are we missing? Please contact us with suggestions and any other ideas you have for keeping the community up to date.


MolPsychCoverFeb11_2021Border.jpgPolygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants.
Saarentaus EC, Havulinna AS, Mars N, Ahola-Olli A, Kiiskinen TTJ, Partanen J, Ruotsalainen S, Kurki M, Urpa LM, Chen L, Perola M, Salomaa V, Veijola J, Männikkö M, Hall IM, Pietiläinen O, Kaprio J, Ripatti S, Daly M, Palotie A.
Mol Psychiatry. 2021 Feb 1.

Certain large genomic rearrangements, called copy number variants (CNVs), raise the risk for neurological and psychiatric disorders in some people. But in most working-age individuals, those high-risk CNVs have little or no impact on well-being, educational attainment or income, according to an analysis of two Finnish cohorts. “Our findings highlight that the contribution of traditional high-risk variants such as CNVs should be analyzed in a broader genetic context, rather than evaluated in isolation,” the authors write. 


Weekly List (Most Recent First)

Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in preeclampsia: a genetic and functional study.
Lokki AI, Teirilä L, Triebwasser M, Daly E, Bhattacharjee A, Uotila L, Llort Asens M, Kurki MI, Perola M, Auro K, Salmon JE, Daly M, Atkinson JP, Laivuori H, Fagerholm S, Meri S; Finnpec.
BJOG. 2021 Feb 4. Online ahead of print.

A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis.
Bell S, Rigas AS, Magnusson MK, Ferkingstad E, Allara E, Bjornsdottir G, Ramond A, Sørensen E, Halldorsson GH, Paul DS, Burgdorf KS, Eggertsson HP, Howson JMM, Thørner LW, Kristmundsdottir S, Astle WJ, Erikstrup C, Sigurdsson JK, Vuckovic D, Dinh KM, Tragante V, Surendran P, Pedersen OB, Vidarsson B, Jiang T, Paarup HM, Onundarson PT, Akbari P, Nielsen KR, Lund SH, Juliusson K, Magnusson MI, Frigge ML, Oddsson A, Olafsson I, Kaptoge S, Hjalgrim H, Runarsson G, Wood AM, Jonsdottir I, Hansen TF, Sigurdardottir O, Stefansson H, Rye D; DBDS Genomic Consortium, Peters JE, Westergaard D, Holm H, Soranzo N, Banasik K, Thorleifsson G, Ouwehand WH, Thorsteinsdottir U, Roberts DJ, Sulem P, Butterworth AS, Gudbjartsson DF, Danesh J, Brunak S, Di Angelantonio E, Ullum H, Stefansson K.
Commun Biol. 2021 Feb 3;4(1):156.

Swedish large-scale schizophrenia study: Why do patients and healthy controls participate?
Dufva YE, Westman H, Khilbom U, Sullivan PF, Johansson V.
Schizophr Res. 2021 Feb 3;228:360-366. Online ahead of print.

DSM-5 and ICD-11 criteria for bipolar disorder: Implications for the prevalence of bipolar disorder and validity of the diagnosis - A narrative review from the ECNP bipolar disorders network.
Kessing LV, González-Pinto A, Fagiolini A, Bechdolf A, Reif A, Yildiz A, Etain B, Henry C, Severus E, Reininghaus EZ, Morken G, Goodwin GM, Scott J, Geddes JR, Rietschel M, Landén M, Manchia M, Bauer M, Martinez-Cengotitabengoa M, Andreassen OA, Ritter P, Kupka R, Licht RW, Nielsen RE, Schulze TG, Hajek T, Lagerberg TV, Bergink V, Vieta E.
Eur Neuropsychopharmacol. 2021 Feb 1:S0924-977X(21)00113-9. Review.

PopDel identifies medium-size deletions simultaneously in tens of thousands of genomes.
Niehus S, Jónsson H, Schönberger J, Björnsson E, Beyter D, Eggertsson HP, Sulem P, Stefánsson K, Halldórsson BV, Kehr B.
Nat Commun. 2021 Feb 1;12(1):730.

Combined effects of genotype and childhood adversity shape variability of DNA methylation across age.
Czamara D, Tissink E, Tuhkanen J, Martins J, Awaloff Y, Drake AJ, Khulan B, Palotie A, Winter SM, Nemeroff CB, Craighead WE, Dunlop BW, Mayberg HS, Kinkead B, Mathew SJ, Iosifescu DV, Neylan TC, Heim CM, Lahti J, Eriksson JG, Räikkönen K, Ressler KJ, Provençal N, Binder EB.
Transl Psychiatry. 2021 Feb 1;11(1):88.

Time-ordered comorbidity correlations identify patients at risk of mis- and overdiagnosis.
Jørgensen IF, Brunak S.
NPJ Digit Med. 2021 Jan 29;4(1):12.

The interplay of genes, lifestyle, and obesity.
Franks PW.
In: Romieu I, Dossus L, Willett WC, editors. Energy Balance and Obesity. Lyon (FR): International Agency for Research on Cancer; 2017. CHAPTER 10. Review.