Nordic Papers (5 March 2021)

A curated list of scholarly publications relevant to research, policy, and health care from the Nordic human genetics and precision medicine community.

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Changes in the fine-scale genetic structure of Finland through the 20th century.
Kerminen S, Cerioli N, Pacauskas D, Havulinna AS, Perola M, Jousilahti P, Salomaa V, Daly MJ, Vyas R, Ripatti S, Pirinen M.
PLoS Genet. 2021 Mar 4;17(3):e1009347.

Image courtesy PLOS Genetics

  • In an analysis of 18,000 Finnish samples drawn from the National FINRISK Study, researchers have captured the evolving fine-scale genetic population structure in Finland during the 20th century. The genetic changes in different regions of the country reflect historical events. The results also provide more precise reference groups within the country to improve genetic risk estimation in medical applications, such as polygenic risk scores. “We expect that our results will help personalize future genomic medicine in the Finnish population and promote the participation of the general public in large-scale biobank collections that provide unprecedented opportunities for human genetic research, in Finland as well as elsewhere in the world,” the authors wrote. The results are available to the general public in an interactive website. (News release)

Weekly List (Most Recent First)

Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark.
Pinna NK, Anjana RM, Saxena S, Dutta A, Gnanaprakash V, Rameshkumar G, Aswath S, Raghavan S, Rani CSS, Radha V, Balasubramanyam M, Pant A, Nielsen T, Jørgensen T, Færch K, Kashani A, Silva MCA, Vestergaard H, Hansen TH, Hansen T, Arumugam M, Nair GB, Das B, Pedersen O, Mohan V, Mande SS.
Genome Med. 2021 Mar 3;13(1):36.

Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India.
Alvarez-Silva C, Kashani A, Hansen TH, Pinna NK, Anjana RM, Dutta A, Saxena S, Støy J, Kampmann U, Nielsen T, Jørgensen T, Gnanaprakash V, Gnanavadivel R, Sukumaran A, Rani CSS, Færch K, Radha V, Balasubramanyam M, Nair GB, Das B, Vestergaard H, Hansen T, Mande SS, Mohan V, Arumugam M, Pedersen O.
Genome Med. 2021 Mar 3;13(1):37.

Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria.
Winther SA, Øllgaard JC, Hansen TW, von Scholten BJ, Reinhard H, Ahluwalia TS, Wang Z, Gæde P, Parving HH, Hazen S, Pedersen O, Rossing P.
PLoS One. 2021 Mar 3;16(3):e0244402.

Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank.
O'Connell KS, Sønderby IE, Frei O, van der Meer D, Athanasiu L, Smeland OB, Alnæs D, Kaufmann T, Westlye LT, Steen VM, Andreassen OA, Hughes T, Djurovic S.
Psychol Med. 2021 Mar 3:1-11. 

Genome-Wide Association Study Identifies LINC01184/SLC12A2 As Risk Locus for Skin and Soft Tissue Infections.
Rogne T, Liyanarachi KV, Rasheed H, Thomas LF, Flatby HM, Stenvik J, Løset M, Gill D, Burgess S, Willer CJ, Hveem K, Åsvold BO, Brumpton BM, DeWan AT, Solligård E, Damås JK.
J Invest Dermatol. 2021 Mar 1:S0022-202X(21)00149-4.

Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial.
von Herrath M, Bain SC, Bode B, Clausen JO, Coppieters K, Gaysina L, Gumprecht J, Hansen TK, Mathieu C, Morales C, Mosenzon O, Segel S, Tsoukas G, Pieber TR; Anti-IL-21–liraglutide Study Group investigators and contributors.
Lancet Diabetes Endocrinol. 2021 Mar 1:S2213-8587(21)00019-X.

Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer.
Helwa R, Gansmo LB, Bjørnslett M, Halle MK, Werner HMJ, Romundstad P, Hveem K, Vatten L, Dørum A, Lønning PE, Knappskog S.
Biomarkers. 2021 Feb 28:1-7. Online ahead of print.

Relationship between insulin sensitivity and gene expression in human skeletal muscle.
Parikh HM, Elgzyri T, Alibegovic A, Hiscock N, Ekström O, Eriksson KF, Vaag A, Groop LC, Ström K, Hansson O.
BMC Endocr Disord. 2021 Feb 27;21(1):32.

Polygenic Risk Scores Predict Hypertension Onset and Cardiovascular Risk.
Vaura F,
Kauko A, Suvila K, Havulinna AS, Mars N, Salomaa V, FinnGen, Cheng S, Niiranen T. Hypertension. 2021 Apr;77(4):1119-1127. Epub 2021 Feb 22.

Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits.
Martin J, Khramtsova EA, Goleva SB, Blokland GAM, Traglia M, Walters RK, Hübel C, Coleman JRI, Breen G, Børglum AD, Demontis D, Grove J, Werge T, Bralten J, Bulik CM, Lee PH, Mathews CA, Peterson RE, Winham SJ, Wray N, Edenberg HJ, Guo W, Yao Y, Neale BM, Faraone SV, Petryshen TL, Weiss LA, Duncan LE, Goldstein JM, Smoller JW, Stranger BE, Davis LK; Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium.
Biol Psychiatry. 2021 Jan 9:S0006-3223(21)00033-0.